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Cancercelllines Resource Documentation

The Cancercelllines genomic information resource contains genome profiling data, somatic mutation information and associated metadata for thousands of human cancer cell lines. Originally spun out of the Progenetix oncogenomic resource with its collection of more than 100’000 individual genomic copy number screening datasets, cancercelllines.org provides an entry point for genomic variants in cell lines as well as for the exploration of related publications.

Citation (Progenetix)

Huang Q, Carrio-Cordo P, Gao B, Paloots R, Baudis M. (2021) The Progenetix oncogenomic resource in 2021. Database (Oxford). 2021 Jul 17
progenetix.org: Progenetix oncogenomic online resource (2022)

Additional Articles & Citation Options

Baudis M, Cleary ML. (2001) Progenetix.net: an online repository for molecular cytogenetic aberration data. Bioinformatics. 17:1228-1229
Cai H, Kumar N, Ai N, Gupta S, Rath P, Baudis M. Progenetix: 12 years of oncogenomic data curation. Nucleic Acids Res (2014) Jan;42
Cai H, Kumar N, Baudis M. (2012) arrayMap: a reference resource for genomic copy number imbalances in human malignancies. PLoS One. 7:e36944.
Baudis M. (2007) Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data. BMC Cancer. 7:226.
Baudis M. (2006) Online database and bioinformatics toolbox to support data mining in cancer cytogenetics. Biotechniques. 40:296-272.

Registration & Licenses

As of March 2012, no specific registration is required for using the Progenetix and related resources. While the data is licensed under CC-BY 4.0 we suggest that you contact Michael Baudis if you plan any commercial use of the database or are interested to incorporate the data into your research projects.

The Progenetix database and cancer genomic information resource was publicly launched in 2001, abnnounced through an article in Bioinformatics. The database & software are developed by the group of Michael Baudis at the University of Zurich and the Swiss Institute of Bioinformatics (SIB).

Additional information - e.g. about contacts or related publications - is available through the group page of the Baudis group at the University of Zürich. For a list of publication by the Baudis group you can go to the group's website, EuropePMC or any of the links here.


Progenetix Source Code

With exception of some utility scripts and external dependencies (e.g. MongoDB) the following projects provide the vast majority of the software (from database interaction to website) behind Progenetix and Beacon+.

bycon

  • Python based service based on the GA4GH Beacon protocol
  • software powering the Progenetix resource
  • Beacon+ implementation(s) use the same code base

progenetix-web

  • website for Progenetix and its Beacon+ implementations
  • provides Beacon interfaces for the bycon server, as well as other Progenetix sevices (e.g. the publications repository)
  • implemented as React / Next.js project
  • contains this documentation tree here as mkdocs project, with files in the docs directory

cancercelllines-web

  • website for cancercelllines.org
  • implemented as React / Next.js project
  • contains this documentation tree here as mkdocs project, with files in the docs directory

PGX

  • a Perl ibrary providing utility functions for Progenetix CNV data
  • used for data transformation, e.g. binning of segmental CNV data
  • main purpose now in providing the various plots (CNV histograms, clusterd CNV profiles, array plots)

Additional Projects

icdot2uberon

  • mappings between ICD-O 3 topographies and UBERON anatomical sites

ICDOntologies

  • mappings between ICD-O 3 morphology / topography pairs and NCIt neoplasm core cancer ontology